What Network&c said. If you are doing frequent backups of your system drive, it may be worth the risk. But in RAID0 you will lose TRIM support, as Net&c said, so your performance goes kerflui.
A thought: Some software always installs itself in "/program files". Some software is really, really thoughtful and asks where you want to install it. Put in a second SSD and re-install all of the thoughtful software on the new drive letter?