Why not? The mobos comes with good chipset for overclock plus you have a good cooler. I think that's possible. But if you want something better, a mobo with 890FX or 790FX chipset is the best option for overclock.
Maybe you can hit the 4.2GHZ stable with a little work and patience and always that your temps stay at 55ºc or below, you are safe to go.