Its an issue with all chipsets and motherboards. The more modules or devices you plug into a multi-drop electrical bus, the more electrical loading is carried over the bus. This is the reason for the existence of Registered DIMMs, which allow the use of more modules at any given operating frequency (with a slight latency penalty).
It has always been the case. Until someone rewrites the laws of physics, it will always be an issue.
I understand that load increases, and I would probably have to adjust voltages in BIOS or somesuch...
But, I'm not sure I follow... is this to say that I should just *expect* to have issues if I try to actually put the full 16GB of RAM in this board? Even given high-quality RAM, and BIOS adjustments?