Check the asus website for vista 64 drivers. Also check your printer website for it's driver. Most devices work fine with it; some virus protection may have issues. I use microsoft's free malware virus software. It's detected trojans twice and removed them without any issues. It works. If you have any favorite xp files, I would look for a deal on windows 7 pro to use with xp virtualization. Any amd dual core made in the last 2 years and most Intel cpus support it, except for sempron and celeron.