No. If the e5300 isn't listed in the "cpu support" section of ecs website, then the motherboard chipset is too old. Time for a new board. I just got a frys combo deal with msi board and celeron 430 for $39.99 after rebate yesterday. It will work with almost any 775 core2 duo or quad core. The special ends today, but frys stores will have more in the next 3 weeks. Or check newegg for an open box board if you live in the us or canada.