Make sure all sata drives have the power supply leads connected. You'll need to do a format and fresh windows installation, or use the hardrive manufacturer's software to prep your hardrives as boot or secondary drives. I use maxblast 5; it will prep the drive(s) and then make an exact drive to drive copy. Don't know why your optical drive doesn't work. If this is the first time changing out a board, you need to do some more reading in the board manual or some faqs on this website.