There is no way to really remove it, but you can make it difficult to access. But first, why would you want to do that? Safe mode is a very important tool to repair Windows, and removing/disabling it can cause you to loose everything if Windows no longer boots normally.
how to remove the safe mode of my laptop
+1 ^^^ Listen to Philfrisbie ! - Sound advice.
But, if you are "stuck" in safe mode, when you boot, and cannot boot normally, that is a different issue.