If your case supports eATX and the PSU is on the bottom, you should not have any issues with the second PCIe slot. I am sorry, if I seem to suggest you get another case, that is what I had to do, but in actually, I am scraping my orginal idea. I just got a 9800GTX+ for my Current PC, after my PNY 8800GTX died, so I am cancelling my SLI set up and going with a whole new setup, XFX 750i, 9800GTX+ in SLI. Too bad, I spend the money on the Artic cooling, but I am keeping them as back up and running one on D975XBX Board.