I'm not sure you can effectively build an air-tight system. And furthermore, PC cooling RELIES on air movement to remove heat. Without air to remove heat via convection (regardless of the method of getting to the surface for air to remove it) you simply have a heat source that continually heats. It would be the same as having a system in an oil submersion with zero flow or movement. Pockets of heat build up right at the hot components and continue to do so until over heating.