I have two D-Link hubs plugged in to my GA-EP45-UD3R and the computer always boots up just fine.
I will note that my wife has a Dell laptop with a IOGEAR hub/card reader plugged in and, if she has a GPS device plugged in for charging and she boots up the laptop, the laptop tries to boot from the GPS and fails. She has to make sure the GPS is unplugged to boot up the laptop.
Perhaps you have something plugged into the hub that the computer does not like or you have the BIOS set to boot from USB devices and it fails? Try booting up the computer with just the hub and nothing else plugged into the hub and see what happens. Also don't forget to plug the hub into all the other USB ports and see if it's a problem only on one port.
Let us know what happens.