Well got this motherboard a P5Q SE PLUS great motherboard stable as a rock but had one little annoying problem my computer refused to go into sleep mode was very annoying. After fiddleing with this for 2 hours i figured out the fix for it so if you have this motherboard you might want to try this.
Main thing is it locks up in sleep mode and the culprit is usually your USB keyboard and mouse so easy fix go to device manager and go to your mouse and keyboard properties and in the power management tab uncheck allow the device to wake the computer do this for mouse and keyboard.
2 other things i did was in bios in power setting suspend mode put on S3 and enable ACPI 2.0
I'm sure im not the only one with the sleep locking up problem on this board
Found this thread because I had the same problem with same mobo. System would not sleep. As soon as my power light started the slow flash that tells you the system is asleep my system would wake up and come right back out of it.
Not having my system wake from mouse or keyboard is not a solution for me but I solved this by setting suspend mode in the bios to S1 only. That was the only setting I had to change either in the bios or in the OS (7 ulitmate 64).
Thougth I would chime in just in case any one else had the same problem. Of course this may not work for everyone but I have the same mobo and this worked fine for me. I did not have to disable wake from mouse or keyboard and can still do this just fine but my system stays asleep now as well.
I actully found the real fix to make the system sleep in S3 mode S1 is diffrent then S3 whole system will shut down fans and all in S3. The real fix is actully jumper settings i figured out reading the manual on the can the other night lols there are two jumpers located by the usb ports near the processor you have to move them into the 2 3 position to activate a 5 volt supply to the USB ports in sleep. As for my first fix if you dont want to open case up turning off wake by mouse and keyboard does solve it and you can still wake by just tapping the power button.
Saaiello is correct. Here is some clarification of all the settings I needed to configure in order for sleep mode to work with Windows 7 & the P5Q SE PLUS motherboard.
Change jumper on motherboard:
Move the USB1-5 Jumper to pins 2&3. It's the blue jumper farthest from the CPU to the left.
Leave the KBPWR jumper where it is. Moving the other jumper achieves the same result.
BIOS (Use DEL at post to access) > POWER >
Suspend Mode = AUTO
Repost Video at S3 Resume = DISABLED
ACPI 2.0 Support = ENABLED
ACPI APIC Support = ENABLED
With these settings... Windows 7 will go to sleep by command or by trigger. You can wake the PC by pressing the spacebar, mouse buttons, or power button.
+1 for changing the setting on the USB jumpers on the board solving the problem.
I have a bit of a different board (ASUS P5Q-EM DO), and the solution is a bit different. There are actually 3 jumpers on my board for USB, labelled "USBPW1-4", "USBPW9-12", and "USBPW5-8". The latter two are set to "+5V" by default, and need to be changed to "+5VSB" in order for it to wake up from S3 mode.
From the motherboard manual: "Set these jumpers to +5V to wake up the computer from S1 sleep mode (CPU stopped, DRAM refreshed, system running in low power mode) using the connected USB devices. Set to +5VSB to wake up from S3 and S4 sleep modes (no power to CPU, DRAM in slow refresh, power supply in reduced power mode)."
Other solutions if you do not want to adjust jumpers include either of:
-Plug USB devices into the rear USB ports; these have "+5VSB" selected by default; that will work with my board using default jumper positions
-In the BIOS, select the "S1" sleep mode instead of "AUTO" or "S3"; that should work if your USB jumpers are set to "+5", though fans may stay running in sleep mode
-As the OP suggested, disable the wake-up option for the keyboard and mouse; this "worked" for me (the computer stayed sleeping), but it obviously did not wake up with the keyboard and mouse, though it did wake with the power button; this may be an adequate solution for some