The fact that it is alienware means nothing other than you spent a lot of money on it. Listing the actual specs of the PC might help. posting something along the lines of this - http://www.tomshardware.com/forum/264823-31-troubleshooting
would really help.
If you can't boot into safe mode, then it is probably a hardware issue. Since you didn't provide any details I can only suggest stripping your PC down to the minimum needed to boot and see what happens. If you can use alternative known working parts that makes it easier to eliminate motherboard problems.