Unable to open folders in my external hard drive,its says the item \'lieuupuux.e

Do a search of your hard drives for lieuupuux.exe. Once you find it, note the location, then in the shortcut properties, change the target to the full path and filename.

i.e. c:\program files\misc\lieuupuux.exe

If you can't find the file on any of the hard drives, it was most likely uninstalled or accidently deleted.