The GENE is a micro ATX board which you are comparing w/ a full size ATX board so I can't quite judge what your criteria are.
If intent is to use a small case for LAN partying, etc, then the GENE makes sense.
If you are looking for extreme overclocking features on an X58, the GENE equivalent in a full size ATX case would be the Rampage II Extreme (R2E). The R3E is supposedly about to hit the streets sometimes soon.
If you are well versed in OC but want an MoBo known for high OC's, the the Asus P6T Deluxe make sense but I'd go w/ the newer V2 (version 2).
If you want the latest and greatest w/ the most upgrade ability, then P6X58D makes the most sense (SATA II / USB 3)
Check this article w/ regards to GFX choices.....only recommendation I can argue with is the 5770.