I agree- limit heat and voltage to reasonable levels and it should last well beyond its useful lifespan. Both of my desktop workstations are overclocked to their limit and I haven't had a problem with either of them. My workstation at work runs 24/7 and has done so for 2.5 years straight. You mention a variety of speeds- most people seem to get 4.5GHz and beyond with the 2600k, but I don't think you can count on getting to 5.0. It will depend on your particular chip and how good your cooling is.