Weird lockups. Never had anything like this before

[omgitsnuc]

I think maybe it could be CPU or mobo related?

Never ever had this happen before. I built this computer about last juneish.

Motherboard - http://www.newegg.com/Product/Product.aspx?Item=N82E16813131753
Video card - nvidia 580GTX
Memory - http://www.newegg.com/Product/Product.aspx?Item=N82E16820233144 - 8 GIGS
CPU - http://www.newegg.com/Product/Product.aspx?Item=N82E16819115070

This randomly started one night. If I'm using IE or firefox or anything and go to use another program everything I click on won't open. Like even if I mouse over them on desktop they dont highlight. If go to switch my channels on mumble it completely locksup. I get no crashes whatsoever and if I CTL ALT DELETE and bring up task bar the computer starts working instantly without forcefully closing anything.

Also games work fine, No freezes or lockups but if I go out of game to maybe surf the internet everything is locked up and unclickable. I bring up task manager and its fine.

I tried reformating , samething, I tried another HD. Same issue. I ran MEMTEST86 and checked out okay. I wouldnt think my video card would cause it... nothing seems to be overheating and I cleaned all the dust out about 2 weeks ago and I always do. I have to think it's down to MOBO or CPU which both have warrantys still. Not sure what could cause this? I flashed my mobo with no luck too. Here is a SS of voltages... http://i.imgur.com/8gODX.jpg

Also Another thing it does is I can't drag and move files to another folder or even icons around the desktop but if I copy I can paste them to other folders. This is on a fresh install which I tried on 2 different HD's. I've searched everywhere and never seen anything like this. I get the lockups going from program to program but If I stay in one program I dont get the issue. It's so damn weird if I CLT ALT DEL and bring up task manager it brings me out of lockout without closing or doing anything.

 

[omgitsnuc]

Just searching the internet. I see other people getting this problem where the computer locks up until they CTL ALT DEL and bring up task manager and it unfreezes. Never needing to click anything, Although I haven't seen anyone fix it really.. Someone said it could be a mouse or USB driver hanging. I didnt do any updating when this started to my mouse drives and I'm on a fresh install so they were all whiped anyway. the ONLY thing I installed the night it started was some sort of progrm that lets me stream videos from my computer to my Ps3 but it's long gone as I'm on a new fresh install.

Maybe I should try to CMOS my mobo?

EDIT-

http://social.technet.microsoft.com/Forums/en-US/itprovistadesktopui/thread/9075972d-21e0-4040-9c5d-48d3c2deda7c

This is my EXACT problem. I have even tried another mouse and it still does it. I suspect it may be USB related with my mobo maybe. I updated USB drives still nothing.