Just a follow up for anyone that cares. ASUS came back with a very terse answer saying "yes, you need to use the old power supply." My old power supply would not work with my desired configuration so I experiment to find out for myself. I cut the lead for the -5V rail and let it run for over a week. No obvious issues so I ordered a new power supply (ATX 2.2). It, too, seems to just work and it powers all of my new devices.
Kudos to the tech support guys at PC Power & Cooling for giving me way more insight than ASUS.