For air cooling I had originally opened up an air passage front to rear so direct airflow would be blowing into the CPUs air cooler, when I went to water cooling that same airflow was still needed to cool the voltage regulators and memory.
Removing the CPU air cooler which was supplying cooling for these components creates a new set of problems as you have to cool these components, I'm sharing this because I have found a fan
that focus's the air directly out from the fan.
They have a demonstration at their website
of how effective this fan is, I have one myself and it does exactly what it's advertised to do, replacing the fan I had in place with this one dropped the M/B temp by 4C, which has my M/B temp 2C above ambient room temp which is very good.
After considering adding a spot cooler to handle the VR area, with this fan in place the results speak for themselves, and you can feel the focused airflow with your hand if you compare this fan against a standard fan.