It's not dangerous to overclock if you don't get greedy. The question is how much you're willing to raise the cpu voltage to get your system stable. There's no guarantee that your system will be stable, especially with 4-6 ram slots filled. 1066 is what the Intel chipset is guaranteed to run at with stability. The asus board may choose 1066 to run as the default setting regardless of the ram brand. Then you may have to set the ram voltage and speed manually. I read the newegg reviews for ram and motherboards even if I purchase the items somewhere else. If newegg carries your amazon ram, then you may get some feedback from users.