Advent PDQ5002 X19 No Beep, No Signal

I have the above pc for 1 year now, I've never changed any of the parts or cards. The PC was turned on for a day or 2 and when I came back to it had a black screen. I turned it off back have been unable to turn it back on. The power light comes on and all fans are working but there is no beep and it does not boot. the screen shows no signal. The monitor and power lead have been checked and no problems there. I opened the PC and found a lot of dust which I have cleaned. I have also cleaned the RAM and tried the PC on/off with different RAM combinations. What should I do>
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