I'm not sure what do you mean by chosing 500GB drives, so you can use all 4 in hybrid raid ....
You can use any drive size you like up to 4 of them. I chosed mine based on price per GB and compatibility list ... Anyway, I'm not questioning your drive choice. I'm simply noting what I use for clarity.
The important matter is that compared to other NAS's in this price cathegory I met - this one is fast, quiet, is great for Linux, is full featured, extremely small/portable and reasonably priced - I'm real user and can recomend it.
Using hybrid raid with 4 disks means that you will end up using it in RAID5 mode, if I understand things right for Synology. I simply selected RAID5 when I put my disks in. One disk for parity is good enough for me - I back up the NAS anyway.
Backup software for what?
* For backing up the NAS - you do not need any SW as it can back itself up to external disks/NAS/ftp/rsync/.....
* If you are talking about backing up my PC to NAS. I do not do that as I do not store any real data on any of my PCs. I use NAS for everything. It saves on disks, data duplications, etc.
* I simply use NAS as network drive on both Linux and visitor's M$ Win machines.
* If I would be backing up Windows PC as system drive. I would most likely boot it to Knoppix and make bzipped image of its system disk/partition/MBR to NAS using dd. That's what I do for virtual machines.
* I do not backup my Linux boxes becuse it is probably faster to reinstall them than backup and recover + patch. Full install with all apps takes less than hour these days. There is no licensing/pirating issue, so I do not face any Windows registration annoyances, re-purchases, etc.
I hope that it makes sense and I did not make many typos