Weird display problems

My wife wanted to move everything into an extra case my sister in law had so i moved hers over.

Before everything worked perfect and now i can only get perfect video if i use onboard video.

If i use my old 8800gt or her 8800 gt it works fine in safe mode but if you boot it in regular they both scramble at the welcome screen and stay scrambled.

I was wondering if anyone had any ideas. My old card worked perfect i just upgraded for a gts 250.

She is running vista home premium i believe.

Thanks