Rather than having a lot of exhaust, what you want is more intake than exhaust to create positive pressure inside the case.
If you have more exhaust than intakes, what you end up doing is forcing the exhaust fans to draw air from vents and the spaces between harddrive brackets, which will inevitably suck in dust.
With positive pressure, all that extra air will force air OUT of those brackets and areas, keeping external dust out. However, if dust gets in, then it will also get stuck going back out...
Solution? Filters on Intake, have lots of them, and a handful of exhaust, and keep a can of compressed air handy for those timely clean-outs (depending on how dusty your house is.)