Most any backup software should be able to handle raid, at least on the backup side. Restoring, on the other hand, can be a problem since some older backup software can't detect a RAID to restore to.
I use Acronis True Image Home to make backups. I used to have a RAID 1 and it had no problems backing up or restoring to RAID.
i backup my most important and unreplaceable files on my 3tb raid5 drive to a 1tb raid1 nas box using syncback.
the nas i use is the dlink dns-323, it's slow and unsuitable for using as a network drive but works fine as place to automatically backup files to nightly.