Most any backup software should be able to handle raid, at least on the backup side. Restoring, on the other hand, can be a problem since some older backup software can't detect a RAID to restore to.
I use Acronis True Image Home to make backups. I used to have a RAID 1 and it had no problems backing up or restoring to RAID.http://www.acronis.com/homecomputing/products/trueimage/
If you are looking for free software, you might want to try Reflect. I haven't tried it on a RAID, but you can try a test run of it.http://www.macrium.com/reflectfree.aspx