Should work fine.
But let me ask: That's a *huge* amount of RAM! What kind of specialized apps do you have that would use that much memory? Are you planning on making a RAMDrive out of some of it?
Reply: I am doing Computational Fluid Dynamics with 1200000 elements, 900000 equations with 1 hour runtimes. Vista/CFD package seem to cache the disk transfers quite well - so no plans for a RAMDrive.