That depends on what you want to do for example when i want a 24/7 overclock so i can just play games and maintain my system nice and cooled down i get the highest clock speed on my lets say graghics card before i need to increase voltage than i leave it at that, or if i want to do a benchmark ill keep going bumping up voltage and everything else to get a high score than bring it back down to my 24/7 overclock but yeah it all depends on you....same goes for CPU and everything else.