Yes. You can plug a 4 pin 12 volt power cable into an 8 pin EPS motherboard connector. However, I do not know if it will work properly with an Intel motherboard. I do know that most Asus motherboards will work with either a 4 pin connection or an 8 pin connection. In fact some Asus motherboards I used came with plastic cover over 4 of the 8 pins. I had to remove the plastic cover to use all 8 pins.
Just to add gigabyte let you do this aswell (there is no plastic cover tho)