For my new build I am planning to purchase Asus Rampage III Formula Motherboard with SupremeFX X-Fi 2 as onboard audio chipset. I currently use M-Audio Studiophile3 as my speakers. These speakers are actually built for studio/monitoring so they offer high quality sounds (http://www.newegg.com/Product/Product.aspx?Item=N82E16836127010). However, most of what I will be doing will be listening to music and gaming. Do you think getting an audio card will make any noticable difference vs using the onboard audio chipset? If so, which audio card do you recommend?