How to run programs from drive other than (C:)?

Hi, I have been using a standard 1tb SATA drive for a while now but I recently bought and installed an 80gb SSD as a boot drive with a few programs on it. My question is:
1) Is there a way to run programs that are installed on my old hard drive, now my data drive, without installing them onto this new drive?
2) If there is, what is the simplest and easiest way to do this?
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