Liquid cooling is really air cooling.
It is just a matter of where the coolant to air heat exchange takes place.
With a liquid cooler, like the H80, the heat from the cpu chip is transferred to a radiator where the fans blow cool air through the radiator to exchange the heat. The heat exchange from the cpu chip to liquid is quite efficient. For best cpu cooling the radiator is mounted to draw cool ourside air into the radiator. Unfortunately, while this is best for cpu cooling, it is not best for cooling the rest of the components, particularly the graphics card.
That is because the heated air is dumped into the case where case cooling has to deal with it.
With a good air cooler, the cpu dissipates heat to heat pipes which transport the heat to the fins of the cooler.
Then the cooler fan sends the hot air out the back of the case, or the top.
In a well ventilated case, like the HAF X, a good air cooler, like the Noctua NH-D14 is about as effective as anything.
I would favor this type of cooler because it will be quieter, cheaper, and more reliable.
How well you can cool in a hot room is determined by how hot the room is to start with. No air coolers can achieve temperatures close to ambient. There will always be some temperature delta. Perhaps 10c?
Should you worry much?
Perhaps not.
If you are talking about sandy bridge or ivy bridge cpu chips, they can tolerate quite a bit of heat before reaching a point where they must downclock to protect themselves from damage. Perhaps on the order of 90-100c.
If you do not overclock, you should have no problem. If you OC to a moderate and conservative level without increasing voltages, then 4.0-4.3 should still not be a problem.
-------------bottom line-----------
NH-D14