I hope I understood the question.
The answer to your question is no. A single SSD used as a cache cannot be used with three separate hard drives. The cache applications were never designed to work that way.
Here is the recommended solution:
SSD #1 is used for Microsoft Windows 7, Adobe products, other software applications, and utilities.
SSD #2 is used as a scratch disk.
Hard disk drives are used to store images and other data.
Adobe published an article about improving CS4 and CS5 performance. Here is the link:http://kb2.adobe.com/cps/404/kb404439.html
Pay attention to the section about solid state drives.