Oh, well then you're going to want something with a bit more to it. Are you stuck on the Core 2 Duo?
A good i5 may be a better choice, but if you're on a strict budget and want to stay on the Core 2 Duo, then I'd consider the ASUS P5Q or the Gigabyte GA-EP45-UD3L. You'll need to add a graphics card, but these boards will give you solid performance. Both also use DDR2 memory, which should be fine for your needs. There are an array of motherboards that support the Core 2 Duo and the newer DDR3 memory, but typically are more expensive and it looks like the pairing doesn't yield any better performance.