Adding two cents since this comes up as a high result in something else I'm looking at doing.
If you are so inclined, you can remove both hard disk caddies, and place the megaflow in front. This is exactly what I did, and it works fine. Bonus points because the front intake fan has zero obstructions, which is difficult to get with ANY case. No modifications necessary, just remove a few thumb screws.
I only have one SSD and one HDD. I mounted the middle caddy to the 5.25" bays and both disks reside in that. (I already use an external bay for my blu-ray drive before I got this setup - I have my optical drive sitting in a different place than my PC for functional reasons. Though I believe you can fit an optical drive in addition to one caddy, but I haven't checked.) Heat doesn't appear to be an issue at all for the disks.
I use a corsair H100i for my CPU cooling, and its radiator replaced the top 200mm fan. I use two Noctua NF-F12 fans on the radiator, blowing inward.
I'm debating whether or not I should get a third NF-F12 for the rear fan, mainly because I want the PWM function. I don't know the physics of static pressure so I am not sure if this is optimal (namely because it will be pushing against the grille.) The search for that landed me here.
My goal is to avoid manual fan control, and allow the system to automatically adjust based on heat output. Any suggestions?