As for the name: Loki/Thor/Odin
Definitely Made and Manufactured in North America. I would build the plant in/around a great technical University, and, very important, try to have a solid working/R&D relationship to said Uni.
Remember, American built and designed. Build-quality should be main concern (I would make the new ASUS Sabertooth and the MSI Mobo's the goal). As for the layout, there isn't that much to do, just keep it simple, clean and make sure access to all components isn't compromised.
I agree. Also get rid of legacy stuff, or make it better. At least for the high end. Replace PATA with say CAT5, or more ______ ports. Make the lay out good, and get rid of excess PCI slots so you can have good spacing. Also, dont be excessive, some motherboard have 6 PCI 2.0 slots. What can you do with all that??? I dont see the point of more than 4, but really more than 2 or 3. Use high quality components, and make it overclocker friendly. Power efficiency and high quality components is something ive seen MSI do really well with lately, and Asus has had some of the better overclockers, so learn from them a little in those areas. For RD, id get half geniuses from the nearest congregation of geniuses, and then get half overclocking enthusiasts. Its nice when the RD people get the board to use 12% less power, but it really comes down to the enthusiasts if they will buy it or not. So they have to like it. Also, US made is good, could be a selling point, and make the boards look nice. I swear, gigabyte boards used to be about as ugly as possible, and when i saw a MSI board and a gigabyte board with equal features, i always got the MSI because they looked better