Have you checked out the black edition sticky up top?
without wanting to jump the gun on that, whats your 'liquid cooling'?
whats your Cpu voltage?
temperatures on load at 4GHz?
I'd drop the ram to a lower speed until you can get stable as well, 1333 works well for my experiments around 4GHz, but I have to drop to even slower for higher clocks above 4.4, and timings set to 10,10,10,30,2T
It may be you are at the point where voltage boosts are needed but if your cooling isn't up to it, don't do it, or you are on a path to a dead chip
**Edit to add Sticky link