Since you got a Rampage III I am guessing you want fast hard drives? Get an SSD as primary boot drive if you can afford it. Something like the OCZ Vertex 2 or the GSkill Phoenix.Then get a mechanical backup drive like the Samsung Spinpoint F3 1TB. It has been on sale for $54 and is a great drive that is fast and reliable.
From anort3; SSD is more expensive, has much less space but is far more quickly than SATAII harddisk. So it's our choice.