Many people have made it to 4.4Ghz without being too high on the Hyper212+. Biggest thing to worry about is the thermal paste application. Learn how to do it before you install it!
I personally can run 4.6Ghz on my 2600k at a voltage offset that pushes me just over 1.3v and stay under 70C with IntelBurnTest and under 65C with Prime95.