Shouldn't be a problem for the vast majority of software/games - almost all installations allow you to change the default install location as part of the process. Create a "GAMES" directory on your HD and install your games there. Thus, the majority of the installation will not be on your SSD.
However, Your C (SSD) drive will also be used as the default location for some content storage for these programs e.g. configurations, game saves. The Save Games location might be of some concern. If you can redirect the save games location then that would be good - unless, like me,
you never, ever, need to do any game saves and complete all games at the one sitting - not.
You'll be noticing a nice difference in your general PC use with your SSD