XP won't run .exe or .com files in safe mode

How can I get Windows XP to run .exe and .com files again. It is not possible to run regedit or any downloaded programs, even in safe mode.
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More about files safe mode
  1. What is the actual message when you try to open an *.exe? (I need to know if it's a virus, a file association problem.......etc.)
    Do U have a win xp cd?
    Did it happened recent?
    Do they have weird icons?
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Security Safe Mode Regedit Windows XP