Though everything works basically perfectly with drivers that come with Windows, you still need proprietary drivers for your hardware. Windows comes with generic drivers.
Example: Windows has drivers for your graphics card. But you want to install manufacturer's drivers to take full advantage of the card, to play games and such. I believe you cannot run crossfire ( you have two display adapters ) without AMD display adapter drivers.
Same is true for other add-on hardware and for components on the motherboard. Chipset, ethernet, audio, storage controllers, etc.
Therefore, you must visit Asus download center to download the most recent drivers for your motherboard.
Windows updates are also very important not only for security but also for application compatibility and reliability.