If your motherboard supports the 250GB hard drive it shouldn't have a problem with the 1.5TB; assuming you have the proper connections for the drive type. Some older motherboards have problems with capacities over 128GB (+-), but that doesn't sound like its the case here. Just make sure you are buying a drive that matches the specifications of the motherboard, e.g. there is no point buying a SATA3 hard drive if your motherboard only has IDE or SATA1 connectors.