First, what motherboard? What OS.
Second, Yes you can do it. Not too difficut either, but you will and should reinstall the OS.
See my signature.
And, it's not connecting the SSD to a HDD, no such thing. Both plug into the mobo.
And NO on the RAID, unless you have a Z68, or Z77 mobo, and use the SSD as a cache drive. But don't! Use the SSD as a boot drive, and the HDD as storage.