Settings when overclocking

What do you guys think about settings like Load Line Calibrations, C states, Spread Spectrum, etc, when overclocking? Everywhere I went there has been some controversy on it, and I'm just trying to get a final general consensus before I do this. I need every change (setting that should be turned on/off) listed, if you can. Thank you.
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  1. My motherboard is an MSI z77 MPOWER and my CPU is an i5 2500k, if that helps.
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