Yes, motherboard damage can cause issues like that.
1. Make sure you have the most up to date drivers and firmware
2. The audio or video problem is likely isolated to just the audio or video. Meaning, if it's a video card issue then it's likely causing the audio to make that sound when the issue occurs and vice versa. If the audio is causing the issue it's likely causing the frame rate to slow or freeze.
3. Try installing a cheap sound card to see if that's the issue.
4. Try installing a different video card and if you use a PCI-e video card, try the onboard video.