The R4 is a beastly mid-tower for water cooling, you can easily stick 2 280mm radiators in/on it, one in the front and another on top.
On topic, yes it would be able to cool the card very well, but I doubt it can be silent under full load. Also depends on whether your CPU cooler is silent under full load.
I think 2x280 radiators that include both CPU and GPU, and 8 low-speed 140mm fans(push pull) would be quietest. More low-speed fans are usually quieter than fewer/single high speed fans of comparable cooling.