Can you access C drive of HD on another motherboard?

Can you recover files off of a C drive by connecting hard drive to another computer's motherboard if the original motherboard crapped out? I am asking this for a friend and frankly I don't have time to go online and research this. I assume that if indeed the drive is still good and the problem is the motherboard that he can just remove the drive and place it in another system to remove the files he wants off his C drive.
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  1. correct. He will need to make sure it boots off the drive already in the system though, and doesn't try to boot off the added drive.
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