The bottom line is, you can safely put a screw in the offending hole and gently/slowly tighten it down. Before doing so, I would recommend you loosen the screws nearest it, slightly, to help with any minor shifting that may take place. Take it slow and easy and you'll be fine.
I am a firm believer in securing all things as they were intended. Screws go where screws go and connectors are always firmly connected (like video cables, etc).