My # 3 Son and I just finished a new build for my wife. MOBO is MSI 890GXM-G65 with the MSI R5770 Hawk for add graphics. Mind you now, she won't go out a slay people or things in some games but, she will do lots of work and "surf da net" some too. We used OCZ AMD Black Edition memory, 8 GB inside a Silverstone GD05 case. It's a little tight but everything works very well. A Seasonic 650W Series X Gold rated is the PSU. So to answer your question, would the 2.1 card & a 2.0 work well. Yes, they do!