Yes. one pci-e slot per card; that card will take up the space next to it (maybe lose one pci slot due to it's width). Measure your case first and be sure you have enough space for the length, so it doesn't make contact with stuff in the back, such as hardrives or other accessories. Also be sure your power supply has the right connection and juice; some newer cards take an 8 pin connector; others still use 6 pin from the ps. I would recommend at least 750w from a reputable brand, such as antec, corsair, seasonic, enermax, or ocz (which I use). A single large 12v rail of 50 amps or more is preferred.