Can you find a Core i5 750 for #1? Maybe a Core i7 860 if it fits in the budget.
CPU: Core i5 750 or Core i7 860
RAM: 4 GB DDR3 G.SKILL Ripjaws DDR3 1600 (PC3 12800) Model F3-12800CL7D-4GBRM
HDD: Seagate Barracuda 7200.12 ST3500418AS 500GB
Video: GTX 465 or HD 5850/5870
PSU: 550W for 1 video card or 750W for 2 video cards
CPU cooler: Hyper 212 Plus
For two 465s a good 650W PSU would do. However neither of the mobos in option 1 would support the full speed a second card could add, so no point getting anything above a good 550W PSU if you go with option 1.
And I vote for the Scythe Mugen 2, as it will be quieter.
I estimate that the second option will cost around €250 more than option 1 with a dual core which isn't ideal for the tasks you are doing. You can bring the performance of option 1 much closer to the performance of option 2 while only spending more on the CPU, to get either an i5-750 or i8-860 like WR2 said.